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TedyphopyDate: Wednesday, 2013-03-27, 0:46 AM | Message # 8611
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Men use women and jettison them, as a development, not having any regard but less denigrating them in the concourse because women are not regimented. Most men are now developing great progenitive spirit and height libido, some are looking against means to augment their life, because of the system women are cheap in the market. Men may give bread and dole, but what did they demand in return. Men may not lose their bounty in behalf of spending on a woman, but a lady-love have to without dubiosity; let go her beloved potentials in her. Marriages are having disturbed because the humankind believes, he bought the daily with his wealth, and so he can do as it pleases him and the lady grace a slave. 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Simon was shocked by Jesus siding with sinners, and some people in the church are also shocked. We consign to oblivion why we are in the Church. What brought us here in the anything else place? The church is a unspoilt bracket as a remedy for decent people, but perchance herein the churchour decency commitment appropriate for more than cultured good manners and middleclass notions of what is okay and proper. Maybe here our decency wish change fianc‚e and our sympathy will wish with passion, which will word itself in compassion instead of those roughly us in the church, outside the church, and largest our exact social network. 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justinfloydDate: Wednesday, 2013-03-27, 1:03 AM | Message # 8612
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Gilead Confirms Positive CHMP Opinion for Stribild; Baxter and Halozyme Announce Positive Opinion for HyQviaStaff and Wire ReportsBioMed ReportsBelow is a look at some of the headlines for companies that made news in the healthcare sector on March 22, 2013.nfgGilead Sciences, Inc. (Nasdaq: GILD) announced that the Committee for Medicinal Products for Human Use (CHMP), the scientific committee of the European Medicines Agency (EMA), has adopted a positive opinion on the company's Marketing Authorisation Application (MAA) for the once-daily, single tablet regimen Stribild for the treatment of HIV-1 infection in adult patients who are antiretroviral-nave or are infected with HIV-1 without known mutations associated with resistance to any of the three antiretroviral agents in Stribild. Stribild combines elvitegravir, an integrase inhibitor, and cobicistat, a pharmacoenhancing agent, with Truvada (emtricitabine and tenofovir disoproxil (as fumarate)). The CHMP's positive recommendation will be reviewed by the European Commission, which has the authority to approve medicines for use in the 27 countries of the European Union (EU).With its potency, tolerability and convenient once-daily dosing, we believe Stribild has the potential to be an important treatment option for patients new to therapy or with no known resistance to any of the three components of the product, said John C. Martin, PhD, Chairman and Chief Executive Officer, Gilead Sciences. We are pleased with today's positive opinion from the CHMP, and anticipate receiving a final decision from the European Commission on our application for Stribild in the coming months.The regulatory filing for Stribild is supported by 48-week data from two Phase 3 double-blind, active-controlled, randomized studies in which Stribild met its primary objective of non-inferiority compared to Atripla (efavirenz 600 mg/emtricitabine 200 mg/tenofovir disoproxil (as fumarate) 300 mg) (Study 102) and to a regimen containing ritonavir-boosted atazanavir plus Truvada (Study 103). In November 2012, data from Studies 102 and 103 were presented at the 11th International Congress on Drug Therapy in HIV Infection in Glasgow, United Kingdom. These data demonstrated that Stribild maintained high antiviral efficacy through 96 weeks of treatment. In all studies, Stribild was well tolerated and most adverse events were mild to moderate. The most common adverse events observed were nausea, diarrhea, upper respiratory tract infection and headache.Stribild has received marketing approval in the United States, Canada, South Korea and Australia. To increase access to Stribild in the developing world, Gilead has granted its Indian manufacturing partners and the Medicines Patent Pool the right to develop and distribute generic versions of Stribild in 100 developing countries. These agreements include a complete technology transfer from Gilead of the manufacturing process for the single tablet regimen.======Baxter International (NYSE: BAX)and Halozyme Therapeutics (NASDAQ: HALO) announced the European Medicines Agency's Committee for Medicinal Products for Human Use (EMA CHMP) has granted a Positive Opinion to Baxter for the use of HyQvia (solution for subcutaneous use) as replacement therapy for adult patients with primary and secondary immunodeficiencies. The product is a combination of human normal immunoglobulin (IGSC, 10%) and recombinant human hyaluronidase, which facilitates the dispersion and absorption of the IGSC.''This recommendation supports our efforts to improve the overall quality of care for patients. This therapy, when approved by the European Commission, would offer patients the option to administer their therapy at home, in a single subcutaneous site every three to four weeks, resulting in potentially lower systemic adverse reactions compared to intravenous treatments,'' said Ludwig Hantson, Ph.D., president of Baxter's BioScience business. ''We look forward to introducing HyQvia as a new patient-friendly therapeutic option for immunodeficient patients.''The application was based on results from a phase III, prospective, open-label, non-controlled design clinical trial, which evaluated the safety and effectiveness of HyQvia in the prevention of acute serious bacterial infections, and the pharmacokinetic parameters compared to immunoglobulin administered intravenously. The objective of the study was to infuse a 3-or 4-week dose of the therapy in a single subcutaneous site. The acute serious bacterial infection rate in the study was 0.025 per patient per year, which is below the required efficacy threshold of 1.0 (serious bacterial infections per patient per year). In the tolerability assessment of HyQvia, the most frequently reported adverse reactions were infusion site reactions (20% of infusions), headache (3% of infusions), fatigue (1% of infusions) and pyrexia (fever) (1% of infusions). Upon receiving marketing authorization from the European Commission, Baxter plans to launch HyQvia in selected countries in the European Union later this year.''Recognizing that the path to approval for any biologic is a long journey, I would like to thank and congratulate the teams at Halozyme and Baxter who have worked tirelessly to advance this therapeutic option for patients,'' said Gregory I. Frost, Ph.D., president and chief executive officer, Halozyme Therapeutics.Also Friday:Advanced Cell Technology, Inc. (OTCBB: ACTC), a leader in the field of regenerative medicine, announced today that its chief scientific officer, Robert Lanza, M.D., will be delivering the Robert M. Nerem Lecture at the 17th Annual Hilton Head Workshop, "Regenerative Medicine: Technologies Enabling Novel Therapies" being held on Hilton Head Island, March 20-23.Alliqua, Inc. (OTCQB:ALQA) ("Alliqua" or the "Company") today announced the initiation of a life-cycle management plan as the first phase in their portfolio expansion initiative.ARIAD Pharmaceuticals, Inc. (NASDAQ: ARIA) today announced that the Committee for Human Medicinal Products (CHMP) of the European Medicines Agency (EMA) has adopted a positive opinion on the marketing authorization application for Iclusig (ponatinib) for two indications.Biogen Idec (NASDAQ: BIIB) announced that it has received a positive opinion from the Committee for Medicinal Products for Human Use (CHMP) in the European Union (EU) recommending a marketing authorization be granted for TECFIDERA (dimethyl fumarate) as a first-line oral treatment for adults with relapsing-remitting multiple sclerosis (RRMS).Dr. Reddys Laboratories (NYSE: RDY)announced today that it had settled its claims against Nordion Inc. (formerly MDS Inc.), headquartered in Ottawa, Canada, in a case pending in the United States District Court for the District of New Jersey, for a cash payment of USD 22.5 Million by Nordion to Dr. Reddys.FluoroPharma Medical, Inc. (OTCQB: FPMI), a company specializing in the development of novel diagnostic imaging products that utilize positron emission tomography (PET) technology for the detection and assessment of disease before clinical manifestation, announced today that it has received a patent covering a platform series of metabolic markers for PET and SPECT imaging.GenVec, Inc. (NASDAQ: GNVC) announced financial results for the fourth quarter and year ended December 31, 2012. For the year ended December 31, 2012, the Company reported a net loss of $14.1 million, or $1.09 per share, compared with a net loss of $7.4 million, or $0.58 per share, for the year ended December 31, 2011.Genzyme, a Sanofi Company (EURONEXT: SAN and NYSE: SNY) announced today that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has issued a positive opinion regarding the approval of once-daily, oral AUBAGIO (teriflunomide) for the treatment of adult patients with relapsing-remitting multiple sclerosis (MS).Gilead Sciences, Inc. (Nasdaq: GILD)today announced that the Committee for Medicinal Products for Human Use (CHMP), the scientific committee of the European Medicines Agency (EMA), has adopted a positive opinion on the companys Marketing Authorisation Application (MAA) for the once-daily, single tablet regimen Stribild for the treatment of HIV-1 infection in adult patients who are antiretroviral-nave or are infected with HIV-1 without known mutations associated with resistance to any of the three antiretroviral agents in Stribild. Stribild combines elvitegravir, an integrase inhibitor, and cobicistat, a pharmacoenhancing agent, with Truvada (emtricitabine and tenofovir disoproxil (as fumarate)).Isis Pharmaceuticals Inc. (NASDAQ: ISIS) today announced that following Genzyme's request for re-examination, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) confirmed its previous position and has maintained a negative opinion regarding the marketing authorization application (MAA) for KYNAMROTM (mipomersen) as a treatment for patients with Homozygous Familial Hypercholesterolaemia (HoFH).Lpath, Inc. (NASDAQ: LPTN), the industry leader in bioactive lipid-targeted therapeutics, received official notification from the European Patent Office (EPO) and the U.S. Patent and Trademark Office (USPTO) that the company has been issued three key patents.pSivida Corp. (NASDAQ:PSDV) (ASX:PVA), a specialty pharmaceutical company that is a leader in the development of sustained release ophthalmic drug treatments, today announced that its licensee Alimera Sciences, Inc. reported a number of updates with respect to ILUVIEN for chronic diabetic macular edema (DME).SK3 Group, Inc. (OTC Pink: SKTO) today announces that its newly acquired subsidiary, Medical Greens, has contracted for over $30 Million in annual licensing, management, and logistic services from collectives throughout California, after only its first full week of operations under SK3 Group, Inc.VG Life Sciences, Inc. 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suttokdrrikDate: Wednesday, 2013-03-27, 1:16 AM | Message # 8613
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SatashiltDate: Wednesday, 2013-03-27, 1:45 AM | Message # 8614
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Expensive? A matter of area, mostly
Travelers familiar with Paris notice retail prices paid for similar merchandise vary from one district to the other. This is especially true for restaurants and clothing. As far as the latter goes, discount shops tend to cluster around certain micro-areas which couture designers and upscale clothiers carefully avoid. Paris is a shopping mosaic.
Say, you are on the Boulevard Saint Germain, in the upper part of the Saint Germain des Prés district. Designer clothing stores, sidewalk cafés et restaurants abound in this area. Draw nearer the river Seine and your footsteps lead you where the art galleries cluster together. Walk a bit to the east, towards rue de Buci, the clothing stores become less expensive.
Turn southwards, and from the church of Saint Germain des Prés, take Rue de Rennes, walking towards the Montparnasse Tower. About 200 yards in the Rue de Rennes, your path crosses the upscale Rue Du Four which is lined with more expensive brands. Continue on up the Rue de Rennes, and you will arrive at the Saint Sulpice metro station. On your right side (west of where you are when you face the Montparnasse Tower), the apparel shops in the surrounding streets offer attractive bargains.
Sales, Sales, Sales in Paris!
In yet another district, close to the Madeleine Church and the Opera Garnier, large department stores found a home on Boulevard Haussmann some 110-140 years ago. Le Printemps department store was constructed there in 1865, and the Galeries Lafayette followed suit in 1893.
Department stores offer a very convenient way of shopping for fashion: thousands of upscale items can be found over acres of floor space. This includes apparel, accessories, perfumes, cosmetics, watches, shoes, and other goodies. A great selection, but bargains are far and between except during the sales seasons.
The latter are a tightly regulated business in France. There are two sales seasons, winter and summer. Their starting dates are a matter of administrative decrees, and each of the two seasons last six weeks only. The Parisian winter sales season starts at the end of January, the summer one begins in late June.
Shopping at designer depots
But outside the sales seasons, shoppers looking for bargain-basement prices and irresistible clearances must look elsewhere. It is my experience that the best bargain prices on clothing offered in Paris are found at designer depots.
Though it has become a brand name in North America, a designer depot is in fact a form of commerce. People like you and me bring in clothes we don't want to wear anymore, and get a little money from the shop owner who will resell our garments for a little more money to other people.
I can see already a few eyebrows raised, their rightful owners objecting that designer depots are only glorified thrift shops or consignment stores. Not so in Paris.
Parisian designer depots are usually owned and managed by ladies with a flair for fashion. A number of them have a professional experience in the fashion industry, and if invited to do so, most of them can tell you right away which dress fits you well.... and which skirt makes you look like you dressed with a potato bag.
Parisian fashion retailers have quite an educated eye, and owners of designer depots are no exception to this rule. And so it goes for the quality of the merchandise they buy, though to each owner her own style. They offer items which have seldom been worn more than one season by their original owners, and are in quasi perfect condition.
Style is a keyword here. In 'designer depot', there is 'designer'. Thus the selection of brand names you can find in any of these treasure troves depends on the style the owner prefers: classic, bourgeois, up and coming, ethnic, boho, and so forth. It is a fascinating business to enter a designer depot, and hunt around for a killer little skirt or dressy pants made by A-list designers, and sold for 20% of the regular retail price.
That's the address, silly!
Now not all designer depots were created equal, and where you go shopping for practically-perfect-in-every-way designer clothes is the true measure of your inside knowledge of the city.
I would like to recommend you three 'petites adresses' [the French for 'best-kept-secret places'] I selected amongst a host of others.
For those of you, ladies, who like the classic look, 'Priscilla' is the shop for you. Priscilla is lady who owns the place. She reveres such signature names as Yves Saint Laurent, Max Mara, Kenzo, Chistian Dior, and Sonya Rykiel. Her prices range from €60 for a skirt, to €75 for a jacket, to €130 for a lady's suit. Priscilla advises you to rummage around, and come to her place with an open mind. The shop is located at 4 rue Mouton- Duvernet, in the 14 th district. The nearest metro station is Mouton-Duvernet. Its opening hours are between 4:00 pm and 7:00 pm on Monday, and between 11:00 am and 7:00 pm from Tuesday to Saturday with a one-hour break at 1:30 pm.
My next address, 'Le Jupon Rouge', is situated at 9 rue de Rochechouart in the 9th district. The owner, Tania, describes here designer depot as 'colorful, ethnic but not hippie, and certainly not classical in style'. Tania offers a selection of up and coming French designers such as Bali Barret (a fencing-style vest for €45, cashmere blend cardigans for €45 to €100) and Vanessa Bruno (wool jackets, €90). She also carries more established signatures such as Agnès B (her signature black jacket is offered at €50), and vintage Ungaro blouses for €45. Ladies looking for shoes can fall for pairs of Stephane Kelian low-cut Cuban boots (€100), Repetto ballerina shoes (€40), or vintage low-heel horse-riding boots (€40-70). Tania opens her doors from Tuesday to Saturday, from 10:30 am to 7:30 pm with a one-hour lunch break at 1:30 pm.
In a totally different style, Griff-Troc is the designer depot you need to lose yourself into when you want to go chic-chic-chic. The owner, Beatrice, chose to specialize in perennial, classic basics in perfect condition. Chic has a heftier price tag, of course, but on the upside Griff-Troc offers brand names for 15-30% of boutique prices. On the shelves at the time I wrote this article, Beatrice had a Chanel suit for €1000 <a href="http://fryebootssaleweb.webs.com/"><strong>Frye Boots </strong></a> (vs. €5000 at Chanel's), a brand-new Chloe bag for €800 (instead of €1200), several astounding evening dresses priced between €1200 and €1500 (Chloe, Dior, D&G, Valentino), and Hermès silk scarfs on offer for only €150. She maintains a full selection of bags, jewels, and fragrances. Chic classic never dies, who cares about whether your Chanel suit is this season's or not? The busy boutique is located in the posh section of the 17 th district, at 119 Boulevard Malesherbes. The nearest metro stations are Villiers and Monceau. Its opening hours are between 10:30 am and 7:00 pm, from Monday to Saturday.
Opening my address book for you
I will come back to you with other names and addresses in future articles on this topic. I personally enjoy shopping these boutiques, and based on the number of smartly dressed women I spot there, I am not alone in the belief that such bargains cannot be let pass. Till then, I salute all unrepentant fashion shoppers!
About the Author:A known author on Paris, Phil Chavanne has helped many travelers on their way to the French capital. Get useful advices and many exclusive tips on Paris at http://www.Paris-Eiffel-Tower-News.com, a free guide featuring information about Paris hotels, interesting shops, and great sightseeing opportunities.
 
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